Image credit: Brandon Martin of Rice University
Introduction
Researchers at Carnegie Mellon University are currently developing the Hybrid Advanced Molecular Manufacturing Regulator, HAMMR. HAMMR is a brand new device that can be implanted in a patient. HAMMR’s job is to act as a cancer treatment by releasing certain immunity proteins when they are needed to fight cancer. This research and work is part of the Targeted Hybrid Oncotherapeutics Regulation, known as THOR, which had received a $45 million award from the Advanced Research Projects Agency for Health, the ARPA-H.
What is HAMMR?
HAMMR is a compact, bioelectronic implant which is smaller than an adult’s finger and designed to be inserted into the patient with little surgery required. HAMMR changes the doses of the immunity proteins in real time, meaning that it does not need to be done manually. Additionally, HAMMR can check for indicators all the time, day or night. The strategy used by Carnegie Mellon researchers is supposed to enhance treatment for extremely challenging cancers such as ovarian and pancreatic cancers.
How does HAMMR work?
The implant uses advanced bioelectronics and synthetic biology to sense inflammatory markers and indicators that are associated with cancer. When the device senses the indicators, it releases immunity proteins. Some of the proteins and antibodies released when the implant is triggered are cytokines and antibodies. These cytokines and antibodies are changed to the patient’s specific needs.
Carnegie Mellon University’s Impact
Carnegie Mellon University’s researchers are mainly contributing to the bioelectronic components and parts of HAMMR. The team at Carnegie Mellon University is led by Professor Tzahi Cohen-Karni. Researchers at Carnegie Mellon are creating the sensing and control systems that allow the device to monitor cancer progression, cancer indicators and adjust dosages according to this information. The researchers’ experience in science and bioengineering is crucial for HAMMR to be a reliable and effective implant.
BY: Aarush Vajha